Cisplatin induced nephrotoxicity mechanism

Author: alyp

August undefined, 2024

WebSep 27, 2024 · Cisplatin induces cancer cell death by binding to the N7 reactive center of purine residues and causes irreversible DNA damage in cancer cells during division ( Dasari and Tchounwou, 2014 ), thus blocking cell division and promoting apoptosis.

Cisplatin nephrotoxicity: a summary of pr…

WebCisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years … WebMay 12, 2024 · The key of anti-tumor effect of cisplatin is damage to DNA of tumor, which also lead to renal injury. 2,3 Some reports link cisplatin poisoning with organelle dysfunction, such as endoplasmic reticulum, cytoskeleton, and mitochondria, both in vivo and in vitro. Apoptosis and necrosis of renal tubular cells play a major role in cisplatin … green beans carbohydrate count

Drug-Induced Nephrotoxicity AAFP

WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … WebCis-dichlorodiammine platinum (II), or cisplatin, is currently among the most widely used agents in the chemotherapy of cancer. The chief limit to its greater efficacy is its … WebMar 29, 2024 · The mechanisms associated with cisplatin-induced AKI (CIAKI) are complex, and the relationship between the key pathways remains unknown. However, it is believed that the detrimental … flowers in the attic chapter 1

Cisplatin nephrotoxicity: new insights and therapeutic …

A nano based approach to alleviate cisplatin induced nephrotoxicity

WebDec 16, 2024 · Introduction. Cisplatin is commonly applied in the treatment of a diversity of solid tumors in medical practice due to its simple administration and great efficacy. 1 Cisplatin efficiency is proportionate to its dose. Nevertheless, cisplatin has a relatively limited safety margin and exhibits significant dose-limiting side effects, such as vomiting, … Webrotection against gentamicin-induced nephrotoxicity in rats (Sandhya et al. 1995). Interestingly, the dose of an antioxi-dant lipoic acid (0.12–0.48 mmole/kg) required to … green beans can nutritionWebJan 3, 2024 · Chemotherapy nephrotoxicity and dose modification in patients with kidney impairment: Molecularly targeted agents and immunotherapies; Cisplatin nephrotoxicity; Classic Kaposi sarcoma: Clinical features, staging, diagnosis, and treatment; Contrast-associated and contrast-induced acute kidney injury: Clinical features, diagnosis, and … green beans baby potatoes with bacon recipe

"WebCisplatin-induced nephrotoxicity is a major adverse event (AE), and the incident rate is approximately 30%. 1 - 3 Three basic mechanisms lead to cisplatin-induced nephrotoxicity, that is, tubular cell toxicity, renal microvasculature vasoconstriction, and proinflammatory effects. 3 Several factors are associated with increased risk of … " - Cisplatin induced nephrotoxicity mechanism

Cisplatin induced nephrotoxicity mechanism

Mechanisms of Cisplatin nephrotoxicity - PubMed

WebThe mechanisms mainly include the transport and metabolism of cisplatin, apoptosis, autophagy, DNA damage, oxidative stress, and inflammation, which work together to … WebSep 1, 2024 · The mechanism of cisplatin-induced nephrotoxicity (CIN) has long been investigated in order to develop preventive/therapeutic drugs. Ferroptosis is a newly identified form of non-apoptotic regulated cell death induced by iron-mediated lipid peroxidation and is involved in the pathophysiology of various diseases. In this study, we …

Did you know?

WebOct 11, 2024 · Experimentally induced sepsis (via LPS) also potentiates the degree of cisplatin-induced hearing loss in mice (Oh et al., 2011). LPS-induced inflammation in … WebThe mechanisms of cisplatin-induced nephrotoxicity are complex and involve multiple pathways and molecules ( Figure 1) [ 92, 93 ]. The cellular pathways of cisplatin injury …

WebNov 14, 2024 · The clinical application of cisplatin is limited by its adverse events, of which nephrotoxicity is the most commonly observed. In a cisplatin-induced pathological response, oxidative stress is one of the upstream reactions which inflicts different degrees of damages to the intracellular material components. Reactive oxygen species (ROS) are … WebThe proteinuria associated with cisplatin nephrotoxicity is attributed to a tubular defect. 32 Hemolytic uremic syndrome has also been described, especially when cisplatin is combined with bleomycin. 33 Sequential …

WebOct 29, 2024 · There is evidence though that necrosis, oxidative stress, inflammation, and apoptosis may play crucial roles in cisplatin-induced nephrotoxicity 5. Cisplatin-induced nephrotoxicity... WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose … {{configCtrl2.info.metaDescription}} Nephrotoxicity from chemotherapeutic agents: clinical manifestations, … Ultrafilterable platinum (UP) disposition was studied in 22 cancer patients receiving … The lowest dose categories of cisplatin (≤100 and 101-250 mg/m(2)) are … Faubel S, Ljubanovic D, Reznikov L, et al. Caspase-1-deficient mice are protected …

WebMar 13, 2024 · Background: Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the …

WebNov 11, 2024 · Introduction. Cisplatin (CDDP), a platinum drug, has been universally utilized to treat bladder cancer, ovarian cancer and other solid tumors (Dasari and Tchounwou, 2014).However, the dominant factor restricting the clinical use of cisplatin is its nephrotoxicity (Zhu et al., 2015).Although hydration is extensively used to eliminate … flowers in the attic film locationWebOct 5, 2014 · Cisplatin induced toxicities, especially nephrotoxicity, seem to be related to a decrease in the intracellular concentrations of GSH and protein bound SH-groups. … flowers in the attic film series charactersWebNov 7, 2024 · In accordance with the above outlined mechanisms, ... (Schisandra sphenanthera extract) against cisplatin-induced nephrotoxicity via Nrf2-mediated defense response. Phytomedicine 22, 528–535 ... green beans carrots onions recipeWebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the … green beans canning recipeWebFeb 24, 2024 · The mechanism of cisplatin-induced renal injury is unclear but appears to be associated with abnormal vacuolization and damage of the proximal tubule ( 17 ). Recent years have seen growing interest in kidney-on-a-chip technology ( 18, 19 ). flowers in the attic film series 2022WebMar 9, 2024 · The mechanism summary of cisplatin-induced nephrotoxicity. The mechanisms mainly include the transport and metabolism of cisplatin, apoptosis, autophagy, DNA damage, oxidative stress, and inflammation, which work together to aggravate AKI induced by cisplatin. flowers in the attic filmsWebOct 13, 2024 · Preclinical studies have provided insights into the cellular and molecular mechanisms of cisplatin nephrotoxicity, which involve intracellular stresses including … green beans chinese translation