Cisplatin resistance mechanism

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August undefined, 2024

WebAfter cisplatin enters the cells, some cisplatin molecules bind to DNA and thus activate the DNA damage-induced apoptosis cascade, 15 while others can avidly bind to cytoplasmic nucleophilic species, such as glutathione … WebNov 4, 2024 · These 13 genes identify a variety of cisplatin-resistance mechanisms including increased transport and detoxification of cisplatin, and mis-regulation of the epithelial to mesenchymal transition. Conclusions. We identified gene signatures in resistant TNBC subtypes indicative of mechanisms of cisplatin. Our results indicate …

Functions of N6-methyladenosine in cancer metabolism: from mechanism …

WebFeb 28, 2024 · Three mechanisms define cisplatin’s direct involvement, demonstrating the chemo-resistant tumor cell phenotype: pre-target, on-target, and post-target resistance [20,21,22]. The first is characterized by reduced intracellular accumulation and increased cisplatin sequestration caused by GSH and other scavengers. WebOct 5, 2014 · The proposed mechanisms of cisplatin resistance include changes in cellular uptake and efflux of cisplatin, increased biotransformation and detoxification in the liver, and increase in DNA repair and anti-apoptotic mechanisms (Gottesman, Fojo et al., 2002) . To overcome resistance, cisplatin is commonly used in combination with some … high st rochester

Cisplatin resistance can be curtailed by blunting Bnip3-mediated ...

WebCisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes Ding-Wu Shen, Lynn M. Pouliot, Matthew D. Hall, and Michael M. Gottesman David R. Sibley, ASSOCIATE EDITOR Author informationCopyright and License informationDisclaimer WebAug 24, 2024 · Components of tumor microenvironment reported to affect cisplatin resistance. These components can contribute to cisplatin resistance through decreased … WebCisplatin DNA damage is repaired through four major mechanisms, including double-strand break repair (DSSR), mismatch repair (MMR), base excision repair (BER), and nucleotide excision repair (NER) ( Figure 2A … high st pizza and pour

Targeted therapy for cisplatin‐resistant lung cancer via …

New Insights into Mechanisms of Cisplatin Resistance: …

WebJul 1, 2001 · Postulated mechanisms of resistance to cisplatin include the following: reduced intracellular accumulation of cisplatin which may arise because of decreased uptake or increased efflux; increased inactivation by intracellular proteins such as glutathione; increased repair of cisplatin adducts; increased ability to replicate past … WebReducing cisplatin accumulation appears to be a major mechanism of acquired resistance. In one study, variants of an ovarian carcinoma line with increasing resistance showed decreasing levels of cisplatin accumulation, which could be measured as early as 5 min following treatment. how many days since may 29 2021WebJun 20, 2024 · We propose here a new mechanism of cisplatin resistance mediated by glutathione transferase (GST) P1-1, as a cisplatin-binding protein. Our results show that … high st sheffield

"WebApr 10, 2024 · Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10–20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. Hence, … " - Cisplatin resistance mechanism

Cisplatin resistance mechanism

Bonn researchers elucidate a mechanism underlying cisplatin resistance ...

WebCisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA followed by activation of several signal transduction pathways … WebSep 5, 2011 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions …

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WebUnfortunately, many cancers initially respond to platinum treatment but when the tumor returns, drug resistance frequently occurs. Resistance to cisplatin is attributed to three molecular mechanisms: increased DNA repair, altered cellular accumulation, and increased drug inactivation. WebJul 1, 2001 · Postulated mechanisms of resistance to cisplatin include the following: reduced intracellular accumulation of cisplatin which may arise because of decreased …

WebJan 1, 2016 · Cisplatin is an alkylating agent capable of forming adducts with macromolecules, particularly with N7 atoms of purine nucleobases. This results in inter- and intra-strand DNA cross-links that bring induce cell cycle arrest mainly in the G 2 /M checkpoint ( Yuan et al., 2003 ). WebJan 10, 2014 · Here, we review the molecular mechanisms of cisplatin resistance. These include methods to reduce cisplatin bioavailability within a cell, and defects in the machinery that produces cell death following cisplatin-induced DNA damage. While overcoming these mechanisms is a potential therapeutic approach that can increase …

WebApr 22, 2024 · In cisplatin-resistant cells, mitochondria are more fragmented and closer to the ER. ... BNIP3-driven mitophagy is involved in cisplatin resistance mechanism. WebCisplatin resistance. Cisplatin combination chemotherapy is the cornerstone of treatment of many cancers. Initial platinum responsiveness is high, but the majority of cancer …

WebAug 24, 2024 · New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment. Although cisplatin has been a pivotal chemotherapy drug in treating …

WebApr 1, 2016 · Resistance to cisplatin occurs by the following molecular mechanisms: altered DNA repair, altered cellular accumulation of drug, and cytosolic inactivation of drug. The processes of resistance were studied in L1210 mouse leukemia cells and human ovarian cancer cells [7], [8], [9], [10]. how many days since may 26th 2021WebApr 13, 2024 · YTHDF1 interacts with the binding motif of GLS1 and increases glutamine uptake to enhance glutamine metabolism in cisplatin-resistant CRC cells. The inhibition of GLS1 leads to an increased sensitivity to cisplatin-induced cell death and YTHDF1 is also a potential target in overcoming resistant colon cancers . In gastric cancer, YTHDF2 … high st runwayWebJan 9, 2024 · Mechanism analysis showed FAM83B interacted with APC to inhibit Wnt pathway activity, causing ovarian cancer cisplatin resistance. We also found FAM83B levels were negative with Wnt pathway ... how many days since may 30 2022WebApr 13, 2024 · Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using … high st service danversWebIt has been established that the mechanism of cisplatin resistance includes reduced drug uptake, increased drug inactivation, increased DNA adduct repair, and inhibition of the … how many days since may 2nd 2022WebCisplatin resistance arises through a multifactorial mechanism involving reduced drug uptake, increased drug inactivation, increased DNA damage repair, and inhibition of transmission of DNA damage recognition signals to the apoptotic pathway. high st salem orWebThe mechanism of action of cisplatin has been associated with ability to crosslink with the urine bases on the DNA to form DNA adducts, preventing repair of the DNA leading to DNA damage and subsequently induces apoptosis within cancer cells. how many days since may 25 2021