Exopolyphosphatase prune1

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August undefined, 2024

WebExopolyphosphatase PRUNE1 Definition: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration … WebOct 26, 2024 · We note that the in vitro exopolyphosphatase activity of Prune is mostly against very short chains (3 to 4 phosphate units in length) (44, 62). In our experiments, Prune was also expressed at...

NMIHBA results from hypomorphic PRUNE1 variants that lack …

WebMar 26, 2024 · NMIHBA is caused by biallelic variants in PRUNE1 encoding prune exopolyphosphatase 1. We provide in-depth clinical description of two affected siblings harboring compound heterozygous variant alleles, c.383G>A (p.Arg128Gln), c.520G>T (p.Gly174*) in PRUNE1 . To gain insights into disease biology, we biochemically … WebPharos : Target Details - PRUNE1 Jump to section: close Descriptive Data Protein Summary Protein Classes IDG Development Level Summary Expression Data Protein Sequence … family trip san antonio

PRUNE1 - Exopolyphosphatase PRUNE1 - Function

WebPrune1 Name prune exopolyphosphatase Synonyms 9230112O05Rik, Prune, Prune-M1 Feature Type protein coding gene IDs MGI:1925152 NCBI Gene: 229589 Alliance gene page Transcription Start Sites 6 TSS Location & Maps more Sequence Map Chr3:95160985-95189387 bp, - strand From Ensembl annotation of GRCm39 Genetic … WebSep 1, 2007 · The exopolyphosphatase/pyrophosphatase groups and the prune group can be readily distinguished since members of the former group carry the sequences DHN and DHH in their motifs II and III,... WebJul 1, 2013 · Description. Prune, a 62 kDa protein, belongs to the DHH family phosphoesterase proteins including RecJ DNA repair exonucleases, … coomera big w

PRUNE1 prune exopolyphosphatase 1 [ (human)]

WebFeb 23, 2024 · PRUNE1 c.933G>A synonymous variant induces exon 7 skipping, disrupts the DHHA2 domain, and leads to an atypical NMIHBA syndrome presentation: Case report and review of the literature - Magyar - 2024 - American Journal of Medical Genetics Part A - Wiley Online Library Advanced Search Citation Search Advanced Search Citation … WebApr 4, 2024 · The PRUNE1 gene, located on chromosome 1q21.3, encodes a 453 amino acid protein, that is, highly expressed in the human fetal brain and involved in the regulation of neuronal migration and proliferation [ 4 ]. It harbors 2 domains DHH (20–172 amino acids) and DHHA2 (215–359 amino acids). coomera anglican college term dates 2023WebExopolyphosphatase. Exopolyphosphatase (PPX) is a phosphatase enzyme which catalyzes the hydrolysis of inorganic polyphosphate, a linear molecule composed of up to … coo mentorship

"WebPRUNE1, prune exopolyphosphatase 1 Vertebrate Orthologs 3 Vertebrate Orthology Source. Alliance of Genome Resources. Human Ortholog PRUNE1, prune exopolyphosphatase 1. Synonyms DRES17, DRES-17, … " - Exopolyphosphatase prune1

Exopolyphosphatase prune1

WebPrune1 Overexpression Constructs, supplied by OriGene, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ... (left panel). Short-chain exopolyphosphatase activity of wild type, D106N* and R128Q* mutants on P3 and P4 determined using fixed-time BIOMOL Green phosphate detection assay (middle and right … WebPrune exopolyphosphatase 1. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. PRUNE1 (DRES-17, H-PRUNE, HTCD37, PRUNE) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). Read more. Disease related genes. Enzymes.

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WebPRUNE1 is ubiquitously expressed across multiple tissues with widespread central nervous system expression during fetal development in humans ( 5 ). Previous studies have implicated PRUNE1 in a complex network of interactions regulating cell cycle and motility, with elevated PRUNE1 expression associated with cancer metastasis ( 6–8 ). WebMar 21, 2024 · PRUNE1 prune exopolyphosphatase 1 Gene ID: 58497, updated on 4-Dec-2024 Gene type: protein coding Also known as: PRUNE; DRES17; HTCD37; NMIHBA; …

WebJan 6, 2024 · NMIHBA is caused by biallelic variants in PRUNE1 encoding prune exopolyphosphatase 1. We provide in-depth clinical description of two affected siblings harboring compound heterozygous variant alleles, c.383G > A (p.Arg128Gln), c.520G > T (p.Gly174*) in PRUNE1. To gain insights into disease biology, we biochemically … WebOct 21, 2024 · The PRUNE1 gene encodes a member of the DHH phosphoesterase family, which are enzymes that hydrolyze phosphoester bonds of a broad spectrum of …

WebApproved name prune exopolyphosphatase 1 Locus type gene with protein product HGNC ID HGNC:13420 Symbol status Approved Previous symbols PRUNE Previous names prune homolog (Drosophila) Alias symbols DRES-17 HTCD37 H-PRUNE Chromosomal location 1q21.3 Gene resources for PRUNE1 Ensembl ENSG00000143363 Curated WebMay 5, 2009 · Exopolyphosphatase PRUNE1 EC number EC:3.6.1.1 ( UniProtKB ENZYME Rhea) Alternative names Drosophila-related expressed sequence 17 ( DRES …

WebTerm: Qualifier: Evidence: With: Reference: Notes: Source: Original Reference(s) (-)-epigallocatechin 3-gallate : multiple interactions: ISO: RGD:1350944: 6480464 ...

WebMar 21, 2024 · PRUNE1 prune exopolyphosphatase 1 Gene ID: 58497, updated on 4-Dec-2024 Gene type: protein coding Also known as: PRUNE; DRES17; HTCD37; NMIHBA; DRES-17; H-PRUNE See all available tests in GTR for this gene Go to complete Gene record for PRUNE1 Go to Variation Viewer for PRUNE1 variants Summary family trips during christmasWebThis protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. coomera basketballhttp://www.informatics.jax.org/marker/MGI:1925152 family trips for christmas breakWeb128337365 (PRUNE1) Enzymes [BR:hcg01000] 3. Hydrolases 3.6 Acting on acid anhydrides 3.6.1 In phosphorus-containing anhydrides 3.6.1.11 exopolyphosphatase 128337365 (PRUNE1) BRITE hierarchy: Other DBs: NCBI-GeneID: 128337365: NCBI-ProteinID: XP_053134263: LinkDB: All DBs: Position: 14. AA seq: family trips for cheapWebExopolyphosphatase PRUNE1 Gene PRUNE1 Source organism Homo sapiens (Human) go to search UniProt Q86TP1 go to UniProt Experimental structures None available in the PDB Biological function Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. family trips for februaryWebFeb 23, 2024 · PRUNE1 c.933G>A synonymous variant induces exon 7 skipping, disrupts the DHHA2 domain, and leads to an atypical NMIHBA syndrome presentation: Case … family trips for christmasWebThis gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an … coomera connector south