WebIntech-Cellular Iron Metabolism WebOct 21, 2024 · The mechanism for regulating ferritin secretion by cellular iron remains unknown. 12 Considering the regulation of intracellular ferritin by iron, when iron levels increase, ferritin is rapidly induced by halting posttranscriptional inhibition through the iron-responsive element–iron-regulatory protein (IRE-IRP) system. 29, 30 This avoids free …
Iron Metabolism and the IRE/IRP Regulatory System: An Update
WebApr 12, 2024 · These processes are regulated by the iron-regulatory protein (IRP)/iron-responsive element (IRE) system and nuclear factor erythroid 2-related factor 2 (Nrf2). Meanwhile, excessive ROS also promotes neuroinflammation by activating the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). WebOct 2, 2008 · The interactions of iron responsive elements (IREs) with iron regulatory proteins (IRPs) coordinately regulate the expression of the genes involved in iron uptake, use, storage, and export at the post-transcriptional level, and represent the main regulatory network controlling cell iron homeostasis. hi how can we help
The role of iron regulatory proteins in mammalian iron
WebSep 17, 2024 · Intracellular iron content is regulated by the Iron Regulatory Element-Iron Regulatory Protein (IRE-IRP) system, whereas systemic iron availability is adjusted to body iron needs chiefly by the hepcidin-ferroportin (FPN) axis. Here, we aimed to review advances in the field that shed light on cell-type-specific regulatory mechanisms that control ... WebSep 1, 1998 · Abstract. Iron regulatory protein-1 (IRP-1), a central cytoplasmic regulator of cellular iron metabolism, is rapidly activated by oxidative stress to bind to mRNA iron-responsive elements. We have … WebSep 6, 2024 · The IRE/IRP system accounts for coordinate post-transcriptional regulation of iron metabolism proteins in cells ( Wang and Pantopoulos, 2011; Muckenthaler et al., … hi how can we help you